Hoda Khorram; Aloasghar Ravasi; Mehdi Hedayati; Ali Samadi; abbasali Gaeini
Volume 20, Issue 3 , September and October 2013, , Pages 389-399
Abstract
Background: Reactive oxygen species have an important role in the development of diabetes and its complications. The purpose of this study was to investigate the effect of eight weeks of resistance training on oxidative stress in heart of diabetic rats.
Material and methods: In an experimental study, ...
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Background: Reactive oxygen species have an important role in the development of diabetes and its complications. The purpose of this study was to investigate the effect of eight weeks of resistance training on oxidative stress in heart of diabetic rats.
Material and methods: In an experimental study, 24 Wistar rats divided into two groups, 1. Resistance training (n = 12), and 2. Control group (n = 12). Induction of diabetes was done by a single intraperitoneal injection of streptozotocin (STZ) at a dose of 50 mg/kg dissolved in phosphate buffer (pH, 4.5). The training protocol consisted of 1 set of 10 climbing with the weight attached to the base of the tail, three times per week and for 8 weeks. Forty eight hours after last training session, animals were anesthetized blood was taken directly from the heart and then the heart removed and left ventricles were isolated and used for biochemical assessments. All the statistical analysis was done by SPSS software version 16. Level of significance was set at α
Abbas Ali Gaeini; Fatemeh Shabkhiz; Ali Samadi; Maryam Khalesi; Fateme Tork
Volume 18, Issue 3 , September and October 2011, , Pages 198-205
Abstract
Background and Purpose: It has been suggested that intracellular adhesion molecules (sICAM-1)، as a new inflammatory marker، are more precise and sensitive markers in predicting cardiovascular diseases، compared with traditional predictive markers. The purpose of this investigation was to study the ...
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Background and Purpose: It has been suggested that intracellular adhesion molecules (sICAM-1)، as a new inflammatory marker، are more precise and sensitive markers in predicting cardiovascular diseases، compared with traditional predictive markers. The purpose of this investigation was to study the effect of discontinuous endurance exercise on sICAM-1 and lipid profile (LDL-C، HDL-C، TG، and TC) of non-athletic male students and to survey the correlation between changes of these variables. Material and methods: This experimental study involved twenty non-athletic male students who signed the written informed consent، and were randomly assigned into experimental (n=12) and control (n=8) groups. The exercise protocol was a graded program، to be performed for 8 weeks three times per week with specific intensity and duration. Blood samples were taken before the first session and after the last session، with 14 hours fasting. Data were analyzed in SPSS 16 using independent and dependent t-test، and Pearson correlation coefficient to determine the correlation of the variables. Level of statistical significance was set at α>0.05. Results: Eight weeks of discontinuous endurance exercise caused 14% decline in sICAM-1 (p=0.0001)، 6% in TC (p=0.001)، 10% in LDL-C (p=0.0001)، 40% in TG (p=0.0001) and 23% increase in HDL-C (p=0.001) in the experimental group. However، there were no significant correlation between sICAM-1 alteration and changes of traditional predictors of cardiovascular diseases (LDL-C، HDL-C، TG، and TC) (p>0.05). Conclusion: Eight weeks of discontinuous endurance exercise may reduce sICAM-1 and improve the lipid profile. These changes can play effective roles in the prevention، control and treatment of atherosclerosis.